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The hepatotoxicity of sinomenine, a constituent of the medicinal plant Sinomenium acutum, is characterized by severe acute damage to the liver accompanied by deterioration of its secretory function. Male Wistar rats were administered 0.8-1.5 g/kg sinomenine intraperitoneally daily for 4 days, or 3 g/kg/day for 21 days. Severe damage to the liver was observed in the 4-day study, characterized by multifocal hepatic necrosis associated with infiltration of mononuclear cells, centrilobular hepatic necrosis, and severe necrosis of the periportal hepatic acini. In the 21-day study, sinomenine caused necrosis of the bile duct epithelium, centrilobular hepatic necrosis, and a significant degree of mitochondrial swelling. Since sinomenine treatment induced an accumulation of liver lipids and lactic acid in blood, hepatic detoxification of metabolites was defective. When hepatocytes were isolated from sinomenine-treated animals, sinomenine was a potent inhibitor of hepatic glycogenolysis. Sinomenine increased the intracellular level of cAMP, and the effects were pronounced at 30 microM. Sinomenine also inhibited cAMP-dependent protein kinase activity in a concentration-dependent manner. Thus, sinomenine-induced hepatotoxicity is characterized by a blockade of hepatic glycogenolysis, a potent inhibition of glycogen synthase activity, and an increase of intracellular cAMP levels, which in
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Lupus erythematosus (LE) is a common systemic autoimmune disease with a range of clinical features. The diagnosis can be difficult and the clinical features vary widely even between individuals with the same disease. To review the eye complications associated with LE. We performed a systematic review of ocular features in systemic LE. We searched MEDLINE, EMBASE, and PUBMED databases for English-language studies published from 1966 to 2009. We also manually searched the references of relevant published articles. Two investigators evaluated each report for eligibility and risk of bias independently. Quality of the articles was assessed using a quality assessment tool. Thirty-three articles were identified for inclusion. We did not find evidence for a link between LE and the ocular features indicated in the included articles. Although the majority of published articles describe LE predominantly in African-Americans, European patients and other ethnic groups are also reported. There are less data on childhood-onset cases. Clinicians should be aware of the disease spectrum in ocular complications. No evidence has been reported for LE being an etiologic factor in any of these ocular features.About This Quiz
Recent polls show just about half of the US population wants to see tax increases on the rich.
Would you like that? So would Andrew Cuomo, who has just signed into law a measure that raises taxes on non-single millionaires (those who make more than $400,000 annually).