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The aims of this study were to determine the levels of CD4+ T cell subsets and Th2-type cytokines, which are involved in chronic inflammation, in psoriasis, and to evaluate the relevance of their assessments. Thirty-three patients with plaque-type psoriasis and 20 age- and sex-matched healthy volunteers were enrolled in the study. The level of circulating CD4+ T cells and intracellular Th2 cytokines (IL-4 and IL-13) were determined by flow cytometry and the human IL-10 enzyme-linked immunosorbent assay. The number of CD4+ T cells and the levels of IL-4 and IL-13 were significantly higher in patients with plaque-type psoriasis. However, the levels of IL-10 were reduced in patients with psoriasis. The results show the relevance of assessing Th2-type cytokines in the evaluation of chronic inflammation in plaque-type psoriasis. never actually get married. “But I have very definitely been in love with her for years. I hope we can date soon, but I don’t think our schedules are compatible.”

Fellow country singer Sam Hunt, who fell head-over-heels for his high school sweetheart in Florida five years ago, says he “heartthrobs” best when he’s competing with the clock.

“I mean, it’s hard to hold a candle to falling in love with someone at the airport when you could be at the airport 30 more years later,” said Hunt, who recently popped the question to girlfriend Katelyn Jae. “The point is that she’s a super high-maintenance girl, which makes it very difficult to slow down and
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