Weidt De Kudde Gods Pdf 15

Weidt De Kudde Gods Pdf 15





 
 
 
 
 
 
 

Weidt De Kudde Gods Pdf 15

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Our privacy notice explains how and why we use your information, as well as your rights and choices.Involvement of MAPK signaling pathway in low-dose x-ray-induced DNA damage repair in rat esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) is the most common malignancy of the esophagus with a poor prognosis. Ionizing radiation is one of the risk factors for the development of ESCC. To investigate the potential molecular mechanisms for DNA damage repair induced by low-dose x-ray radiation in rat esophageal squamous cell carcinoma (RENCA) cells. Cell viability was measured by MTT assay. γH2AX foci and comet assays were used for assessing DNA damage. The expression and phosphorylation levels of some key molecules involved in DNA damage repair such as WISP1, ATM, CHK2, p53, RPA, and Rad51, were detected by Western blot analysis. Cell cycle and apoptosis analysis were performed to explore the possible mechanisms. Data showed that high-dose x-rays could induce apoptosis and damage DNA of RENCA cells, but low-dose x-rays could not. Low-dose x-rays could decrease the formation of γH2AX foci in RENCA cells in a dose-dependent manner. The comet assay showed that low-dose x-rays induced DNA damage and reduced the ability of DNA damage repair in RENCA cells. Mechanistically, low-dose x-rays could decrease the expression of the DNA damage repair molecule, WISP1, but it had no effect on the expression of p53, RPA, ATM, CHK2, and Rad51. Low-dose x

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